Ionotropic and metabotropic activation of a neuronal chloride channel by serotonin and dopamine in the leech Hirudo medicinalis.

@article{Ali1998IonotropicAM,
  title={Ionotropic and metabotropic activation of a neuronal chloride channel by serotonin and dopamine in the leech Hirudo medicinalis.},
  author={Declan William Ali and Stefano Catarsi and Pierre Drapeau},
  journal={The Journal of physiology},
  year={1998},
  volume={509 ( Pt 1)},
  pages={211-9}
}
1. Cl- channels on the pressure-sensitive (P) neuron in the leech are directly activated by synaptic release of serotonin (5-HT) and are indirectly stimulated by the cAMP second messenger pathway, suggesting an unusual dual regulation of the channels. We have investigated the mode of action of 5-HT and dopamine (DA) on a Cl- channel in adult P cells in culture by recording from cell-attached patches. 2. 5-HT increased Cl- channel activity only when included in the recording pipette and not when… CONTINUE READING
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