Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

  title={Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.},
  author={Shirley Gil-Parrado and Amaury Fern{\'a}ndez-Montalv{\'a}n and Irmgard Assfalg-Machleidt and O. Popp and Felix Bestvater and Andreas Holloschi and Tobias A. Knoch and Ennes A. Auerswald and Katherine M. Welsh and John C. Reed and Hans Fritz and Pablo Fuentes-Prior and Eberhard Spiess and Guy Salvesen and Werner Machleidt},
  journal={The Journal of biological chemistry},
  volume={277 30},
Ubiquitous calpains (mu- and m-calpain) have been repeatedly implicated in apoptosis, but the underlying mechanism(s) remain(s) to be elucidated. We examined ionomycin-induced cell death in LCLC 103H cells, derived from a human large cell lung carcinoma. We detected hallmarks of apoptosis such as membrane blebbing, nuclear condensation, DNA ladder formation, caspase activation, and poly-(ADP-ribose)polymerase cleavage. Apoptosis was prevented by preincubation of the cells with the calpain… CONTINUE READING


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