Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII

Abstract

Ionizing radiation (IR) is an integral part of modern multimodal anti-cancer therapies. IR involves the formation of reactive oxygen species (ROS) in targeted tissues. This is associated with subsequent cardiac dysfunction when applied during chest radiotherapy. We hypothesized that IR (i.e., ROS)-dependently impaired cardiac myocytes’ Ca handling might… (More)
DOI: 10.1007/s00395-013-0385-6

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