Ionizing radiation induces up-regulation of functional beta1-integrin in human lung tumour cell lines in vitro.

@article{Cordes2002IonizingRI,
  title={Ionizing radiation induces up-regulation of functional beta1-integrin in human lung tumour cell lines in vitro.},
  author={Nils Cordes and Marcel A. Blaese and Viktor Meineke and Dirk van Beuningen},
  journal={International journal of radiation biology},
  year={2002},
  volume={78 5},
  pages={
          347-57
        }
}
PURPOSE Cell-matrix interactions are in part mediated through the beta1-integrin pathway regulating cell survival, proliferation, adhesion and migration. This study was performed to elucidate alterations of expression of the beta1-integrin and its co-localized protein kinase, integrin-linked kinase (ILK), after exposure to ionizing radiation in two lung carcinoma cell lines in the presence or absence of different beta1-integrin-dependent matrix proteins. MATERIALS AND METHODS Exponentially… CONTINUE READING
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