Ionizing radiation-induced gene expression changes in TP53 proficient and deficient glioblastoma cell lines.

@article{Godoy2013IonizingRG,
  title={Ionizing radiation-induced gene expression changes in TP53 proficient and deficient glioblastoma cell lines.},
  author={Paulo R.D.V. Godoy and Stephano S Mello and Daniele Aparecida Rosa Magalh{\~a}es and Fl{\'a}via Sacilotto Donaires and Patr{\'i}cia Nicolucci and Eduardo Ant{\^o}nio Donadi and Geraldo Aleixo Passos and Elza Tiemi Sakamoto-Hojo},
  journal={Mutation research},
  year={2013},
  volume={756 1-2},
  pages={
          46-55
        }
}
The genetic heterogeneity presented by different cell lines derived from glioblastoma (GBM) seems to influence their responses to antitumoral agents. Although GBM tumors present several genomic alterations, it has been assumed that TP53, frequently mutated in GBM, may to some extent be responsible for differences in cellular responses to antitumor agents, but this is not clear yet. To directly determine the impact of TP53 on GBM response to ionizing radiation, we compared the transcription… Expand
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