Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up.

  title={Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up.},
  author={Julien Vignard and Gladys Mirey and Bernard Salles},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  volume={108 3},
The occurrence of DNA double-strand breaks (DSBs) induced by ionizing radiation has been extensively studied by biochemical or cell imaging techniques. Cell imaging development relies on technical advances as well as our knowledge of the cell DNA damage response (DDR) process. The DDR involves a complex network of proteins that initiate and coordinate DNA damage signaling and repair activities. As some DDR proteins assemble at DSBs in an established spatio-temporal pattern, visible nuclear foci… CONTINUE READING
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