Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways.

@article{Park2006IonizingRE,
  title={Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways.},
  author={Chang-Min Park and M Park and Hee-Jin Kwak and H Lee and Mi-Suk Kim and Seunghoon Lee and I. -S. Park and Chang Hun Rhee and S I Hong},
  journal={Cancer research},
  year={2006},
  volume={66 17},
  pages={8511-9}
}
Glioblastoma is a severe type of primary brain tumor, and its highly invasive character is considered to be a major therapeutic obstacle. Several recent studies have reported that ionizing radiation (IR) enhances the invasion of tumor cells, but the mechanisms for this effect are not well understood. In this study, we investigated the possible signaling mechanisms involved in IR-induced invasion of glioma cells. IR increased the matrix metalloproteinase (MMP)-2 promoter activity, mRNA… CONTINUE READING
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