Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells.

@article{Meng2003IonizingRA,
  title={Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells.},
  author={Aimin Meng and Yong Wang and Gary Van Zant and Daohong Zhou},
  journal={Cancer research},
  year={2003},
  volume={63 17},
  pages={5414-9}
}
Exposure of murine bone marrow (BM) cells to ionizing radiation (IR; 4 Gy) resulted in >95% inhibition of the frequency of various day types of cobblestone area-forming cells in association with the induction of apoptosis in hematopoietic stem cell alike cells (Lin(-) ScaI(+) c-kit(+) cells; IR: 64.8 +/- 0.4% versus control: 20.4 +/- 0.5%; P < 0.001) and progenitors (Lin(-) ScaI(-) c-kit(+) cells; IR: 46.2 +/- 1.4% versus control: 7.8 +/- 0.5%; P < 0.001). Incubation of murine BM cells with… CONTINUE READING

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