Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells

@article{Contessa2002IonizingRA,
  title={Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells},
  author={Joseph N. Contessa and Jaime Hampton and Guido M Lammering and Ross B. Mikkelsen and Paul Dent and Kristoffer Valerie and Rupert K A Schmidt-Ullrich},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={4032-4041}
}
In this study we have investigated the effects of low dose ionizing radiation (2 Gy) on p70 S6 kinase and Akt signaling with respect to Erb-B receptors in both the A431 squamous and the MDA-MB-231 mammary carcinoma cell lines. Ionizing radiation caused a 2–3-fold increase in p70 S6 kinase activity that was blocked pharmacologically using an EGFR inhibitor (AG1478) alone, or in combination with an Erb-B2 inhibitor (AG825). These results suggested that both EGFR and Erb-B2 receptors could… CONTINUE READING