Ionizing non-fatal whole-body irradiation inhibits Ca2+-dependent K+ channels in endothelial cells of rat coronary artery: possible contribution to depression of endothelium-dependent vascular relaxation.

@article{Tishkin2007IonizingNW,
  title={Ionizing non-fatal whole-body irradiation inhibits Ca2+-dependent K+ channels in endothelial cells of rat coronary artery: possible contribution to depression of endothelium-dependent vascular relaxation.},
  author={Sergey M Tishkin and Vladimir V Rekalov and Irina V. Ivanova and Robert S. Moreland and Anatoly I. Soloviev},
  journal={International journal of radiation biology},
  year={2007},
  volume={83 3},
  pages={161-9}
}
PURPOSE The goal of this study was to evaluate the influence of ionizing irradiation on large conductance Ca2+-dependent potassium (BKCa) channels in rat coronary endothelial cells. MATERIALS AND METHODS Rats were exposed to a 6 Gy dose from a cobalt60 source. Experimental design of this study comprised recording of contractile force using isolated rat aortic rings and whole-cell patch clamp techniques to study whole-cell potassium currents in isolated rat coronary artery endothelial cells… CONTINUE READING