Ionizing Radiation and Leukemia Mortality among Japanese Atomic Bomb Survivors, 1950–2000

  title={Ionizing Radiation and Leukemia Mortality among Japanese Atomic Bomb Survivors, 1950–2000},
  author={David B Richardson and Hiromi Sugiyama and Nobuo Nishi and Ritsu Sakata and Yukiko Shimizu and Eric J Grant and Midori Soda and W. L. Hsu and Akihiko Suyama and Kazunori Kodama and Fumiyoshi Kasagi},
  booktitle={Radiation research},
Abstract This paper provides the first comprehensive report on mortality by type of leukemia among the Japanese atomic bomb survivors in the Life Span Study (LSS). Analyses include 310 deaths due to leukemia during the period 1950–2000 among 86,611 people in the LSS. Poisson regression methods were used to evaluate associations between estimated bone marrow dose and leukemia mortality. Attention was given to variation in the radiation dose–leukemia mortality association by time since exposure… 
The Incidence of Leukemia, Lymphoma and Multiple Myeloma among Atomic Bomb Survivors: 1950–2001
Analysis of radiation effects on leukemia, lymphoma and multiple myeloma incidence in the Life Span Study cohort of atomic bomb survivors updated 14 years since the last comprehensive report on these malignancies found that ERR models can often provide equivalent and sometimes more parsimonious descriptions of the excess risk than EAR models.
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Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview of Cancer and Noncancer Diseases
The risk of cancer mortality increased significantly for most major sites, including stomach, lung, liver, colon, breast, gallbladder, esophagus, bladder and ovary, whereas rectum, pancreas, uterus, prostate and kidney parenchyma did not have significantly increased risks.
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It is suggested that the risk of radiation-induced hematological malignancies has persisted for six decades since the initial exposure to atomic bomb radiation.
Risk of childhood leukemia after low-level exposure to ionizing radiation
It is shown that for those exposed as children, the proportional increase in the risk of leukemia is expressed over time as a distinct ‘wave’.
Radiation effects on cancer risks in the Life Span Study cohort.
In view of the nature of the continuing increase in solid cancers, the LSS should continue to provide important new information on cancer risks, as most survivors still alive today were exposed to the atomic bomb radiation under the age of 20 y and are now entering their cancer-prone years.
Radiation and cancer risk in atomic-bomb survivors
  • K. Kodama, K. Ozasa, T. Okubo
  • Medicine
    Journal of radiological protection : official journal of the Society for Radiological Protection
  • 2012
Given the continuing solid cancer increase in the survivor population, the LSS will likely continue to provide important new information on radiation exposure and solid cancer risks for another 15–20 years, especially for those exposed at a young age.
Epidemiological research on radiation-induced cancer in atomic bomb survivors
  • K. Ozasa
  • Medicine
    Journal of radiation research
  • 2016
The late effects of exposure to atomic bomb radiation on cancer occurrence have been evaluated by epidemiological studies on three cohorts: a cohort of atomic bomb survivors (Life Span Study; LSS),
Examining temporal effects on cancer risk in the international nuclear workers’ study
Persistent or late effects suggest additional follow‐up may inform on lifetime risks, and cautious interpretation of results is needed due to analytical limitations and a lack of confirmatory results from other studies.


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This paper presents an analysis of data on the incidence of leukemia, lymphoma and myeloma in the Life Span Study cohort of atomic bomb survivors during the period from late 1950 through the end of
Cancer risk among atomic bomb survivors. The RERF Life Span Study. Radiation Effects Research Foundation.
It is important to continue long-term follow-up of this cohort to document the changes with time since exposure and to provide direct rather than projected risks over the lifetime of an exposed individual.
Incidence of leukemia in survivors of the atomic bomb in Hiroshima and Nagasaki, Japan.
Cancer incidence in atomic bomb survivors. Part I: Use of the tumor registries in Hiroshima and Nagasaki for incidence studies.
Questions of data quality in the context of the Life Span Study (LSS) cohort, the major atomic bomb survivor population, are discussed and no significant associations were found between radiation dose and data quality as measured by various indices.
Studies of the mortality of A-bomb survivors, report 7. Part III. incidence of cancer in 1959-1978, based on the tumor registry, Nagasaki.
The incidence of malignant tumors in the RERF Life Span Study sample in Nagasaki as revealed by the Nagasaki Tumor Registry was investigated and the shape of the dose-response curve for gamma exposures was examined.
A-bomb data: detection of bias in the Life Span Study cohort.
  • A. Stewart
  • Medicine
    Environmental health perspectives
  • 1997
By drawing a distinction between A-bomb survivors with and without bomb-related injuries, it was possible to see that instead of the Life Span Study (LSS) cohort being a normal, homogenous
Effect of Recent Changes in Atomic Bomb Survivor Dosimetry on Cancer Mortality Risk Estimates
Although it was anticipated that the new dosimetry system might reduce some apparent dose overestimates for Nagasaki factory workers, this did not materialize, and factory workers have significantly lower risk estimates.
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The idea that HTLV‐1 infection is not associated with an increased general cancer risk is supported, and confounding by hepatitis C virus (HCV) and the interaction between HT LV‐1 and HCV may explain the increased risk of liver cancer among HTLV-1 carriers.
A Hypothesis: Radiation-Related Leukemia is Mainly Attributable to the Small Number of People who Carry Pre-existing Clonally Expanded Preleukemic Cells
This preleukemic clone hypothesis explains various known characteristics of radiation-related ALL and implies that people who do not have substantial numbers of preleukmic cells are likely at low risk of developing leukemia.
Selection Bias in Cancer Risk Estimation from A-Bomb Survivors
Considering the possible bias in cancer risk estimation from A-bomb survivors due to selection of the cohort by survival, indications are that the bias in relative risks is unlikely to be as large as 0.05 to 0.07.