Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases.

@article{Wang2016IonizingRE,
  title={Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases.},
  author={Yingying Wang and Marjan Boerma and Daohong Zhou},
  journal={Radiation research},
  year={2016},
  volume={186 2},
  pages={153-61}
}
Exposure to ionizing radiation induces not only apoptosis but also senescence. While the role of endothelial cell apoptosis in mediating radiation-induced acute tissue injury has been extensively studied, little is known about the role of endothelial cell senescence in the pathogenesis of radiation-induced late effects. Senescent endothelial cells exhibit decreased production of nitric oxide and expression of thrombomodulin, increased expression of adhesion molecules, elevated production of… CONTINUE READING