Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis.

  title={Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis.},
  author={Changzhao Li and Mohammad Athar},
  journal={Radiation research},
  volume={185 3},
This commentary summarizes studies showing risk of basal cell carcinoma (BCC) development in relationship to environmental, occupational and therapeutic exposure to ionizing radiation (IR). BCC, the most common type of human cancer, is driven by the aberrant activation of hedgehog (Hh) signaling. Ptch, a tumor suppressor gene of Hh signaling pathway, and Smoothened play a key role in the development of radiation-induced BCCs in animal models. Epidemiological studies provide evidence that humans… CONTINUE READING
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