Ionization and Divalent Cation Complexation of Quinolone Antibiotics in Aqueous Solution

@inproceedings{Park1996IonizationAD,
  title={Ionization and Divalent Cation Complexation of Quinolone Antibiotics in Aqueous Solution},
  author={H G Park and Kwang-Young Chung and Hyeong-Chul Lee and Jin-Ki Lee and K S Bark},
  year={1996}
}
The protonation and divalent cation complexation equilibria of several quinolone antibiotics such as nalidixic acid (NAL), flumequine (FLU), oxolinic acid (OXO), ofloxacin (OFL), norfloxacin (NOR) and enoxacin (ENO) have been examined by potentiometric titration and spectrophotometric method. The antibacterial activity of these drugs depends upon the pH and… CONTINUE READING