Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model.

@article{Courtemanche1999IonicTF,
  title={Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model.},
  author={Marc Courtemanche and Rafael J. Ramirez and Stanley Nattel},
  journal={Cardiovascular research},
  year={1999},
  volume={42 2},
  pages={477-89}
}
UNLABELLED Recent advances in molecular electrophysiology have made possible the development of more selective ion channel blockers for therapeutic use. However, more information is needed about the effects of blocking specific channels on repolarization in normal human atrium and in atrial cells of patients with atrial fibrillation (AF). AF-induced electrical remodeling is associated with reductions in transient outward current (Ito), ultrarapid delayed rectifier current (IKur), and L-type… CONTINUE READING
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