Ionic requirements of proximal tubular sodium transport. III. Selective luminal anion substitution.

@article{Green1979IonicRO,
  title={Ionic requirements of proximal tubular sodium transport. III. Selective luminal anion substitution.},
  author={Roger P. H. Green and John Hillman Bishop and Kristensen G. H. Giebisch},
  journal={The American journal of physiology},
  year={1979},
  volume={236 3},
  pages={
          F268-77
        }
}
The effect of substitution of luminal anions on sodium and fluid absorption in rat renal proximal convoluted tubules was studied with continuous luminal microperfusion methods. Substitution of bicarbonate in the control Ringer perfusion fluid by 25 mM acetate reduced net sodium reabsorption by 40%; substitution by chloride reduced it by 25%; and substitution by cyclamate reduced it by 70%. Infusion of acetazolamide reduced net sodium and fluid transport in all cases except chloride-Ringer… CONTINUE READING
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