Ionic modulation of the effects of heparin on plasminogen activation by tissue plasminogen activator: the effects of ionic strength, divalent cations, and chloride.

@article{Young1992IonicMO,
  title={Ionic modulation of the effects of heparin on plasminogen activation by tissue plasminogen activator: the effects of ionic strength, divalent cations, and chloride.},
  author={Thomas S. Young and Jay M. Edelberg and Sharon H. Stack and Salvatore Vincent Pizzo},
  journal={Archives of biochemistry and biophysics},
  year={1992},
  volume={296 2},
  pages={
          530-8
        }
}
Ionic strength, divalent cations, and Cl- modulate the ability of the glycosaminoglycan heparin to stimulate the activation of human plasminogen (Pg) by tissue-type Pg activator. Kinetic analysis of Pg activation indicates that heparin is inhibitory, stimulatory, or nonstimulatory as a function of ionic strength. While increasing ionic strength inhibits Pg activation in the absence of heparin, in it presence an activation phase followed by an inhibitory phase is observed. Divalent cations… CONTINUE READING
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