Ionic mechanisms of the cardiac pacemaker potential.

  title={Ionic mechanisms of the cardiac pacemaker potential.},
  author={Akinori Noma},
  journal={Japanese heart journal},
  volume={37 5},
The experimental evidence so far described in the literature is reviewed to explain the ionic mechanisms underlying the cardiac pacemaker potential in the sinoatrial node cell. Following gating mechanisms underlie the slow diastolic depolarization of the SA node cells. The delayed rectifier K+ channels (mainly the rapidly activated component of the delayed rectifier K+ currents, which is blocked by E-4031) activated during the preceding action potential are deactivated during diastole. The… CONTINUE READING