Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors.

Abstract

Gamma-aminobutyric acid A (GABAA) receptors are the principal mediators of synaptic inhibition, and yet when intensely activated, dendritic GABAA receptors excite rather than inhibit neurons. The membrane depolarization mediated by GABAA receptors is a result of the differential, activity-dependent collapse of the opposing concentration gradients of… (More)

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@article{Staley1995IonicMO, title={Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors.}, author={Kevin J Staley and Brandi L Soldo and William Ross Proctor}, journal={Science}, year={1995}, volume={269 5226}, pages={977-81} }