Ionic mechanisms of burst firing in dissociated Purkinje neurons.

  title={Ionic mechanisms of burst firing in dissociated Purkinje neurons.},
  author={Andrew M Swensen and Bruce P. Bean},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={23 29},
Cerebellar Purkinje neurons have intrinsic membrane properties that favor burst firing, seen not only during complex spikes elicited by climbing fiber input but also with direct electrical stimulation of cell bodies. We examined the ionic conductances that underlie all-or-none burst firing elicited in acutely dissociated mouse Purkinje neurons by short depolarizing current injections. Blocking voltage-dependent calcium entry by cadmium or replacement of external calcium by magnesium enhanced… CONTINUE READING
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