Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs.

@article{Jost2013IonicML,
  title={Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs.},
  author={Norbert Jost and L{\'a}szl{\'o} Vir{\'a}g and Philippe Comtois and Bal{\'a}zs Ord{\"o}g and Vikt{\'o}ria Szuts and Gy{\"o}rgy Sepr{\'e}nyi and Mikl{\'o}s Bitay and Zs{\'o}fia Kohajda and Istv{\'a}n Koncz and Norbert Nagy and Tam{\'a}s Sz{\'e}l and J{\'a}nos Magyar and Maria J{\'u}lia Kovacs and L{\'a}szl{\'o} G. Pusk{\'a}s and Csaba Lengyel and Erich Wettwer and Ursula Ravens and P{\'e}ter P{\'a}l N{\'a}n{\'a}si and Julius Gy Papp and Andr{\'a}s Varr{\'o} and Stanley Nattel},
  journal={The Journal of physiology},
  year={2013},
  volume={591 17},
  pages={4189-206}
}
The species-specific determinants of repolarization are poorly understood. This study compared the contribution of various currents to cardiac repolarization in canine and human ventricle. Conventional microelectrode, whole-cell patch-clamp, molecular biological and mathematical modelling techniques were used. Selective IKr block (50-100 nmol l(-1) dofetilide) lengthened AP duration at 90% of repolarization (APD90) >3-fold more in human than dog, suggesting smaller repolarization reserve in… CONTINUE READING