Ionic mechanisms in glutamate-induced astrocyte swelling: role of K+ influx.

  title={Ionic mechanisms in glutamate-induced astrocyte swelling: role of K+ influx.},
  author={Alex S. Bender and Arne Schousboe and Winfried Reichelt and M D Norenberg},
  journal={Journal of neuroscience research},
  volume={52 3},
L-Glutamate (L-GLU) induced astrocyte swelling in a time- and concentration-dependent, as well as Na+- and Ca2+-dependent, and Cl(-)-independent manner. Swelling was prevented by MK-801, cystine, and ouabain. Since L-GLU swelling is ionically dependent, we determined the role of various ions in such swelling. Our results indicate that K+ uptake plays a major role in the mechanism of L-GLU-induced astrocyte swelling. Like swelling, K+ uptake is dependent on Ca2+ and Na+, but not on Cl-. Likewise… CONTINUE READING


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