Ionic mechanism of electrical alternans.

  title={Ionic mechanism of electrical alternans.},
  author={Jeffrey J. Fox and Jennifer L McHarg and Robert F. Gilmour},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={282 2},
Although alternans of action potential duration (APD) is a robust feature of the rapidly paced canine ventricle, currently available ionic models of cardiac myocytes do not recreate this phenomenon. To address this problem, we developed a new ionic model using formulations of currents based on previous models and recent experimental data. Compared with existing models, the inward rectifier K(+) current (I(K1)) was decreased at depolarized potentials, the maximum conductance and rectification of… CONTINUE READING
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Larger late sodium current in M cells contributes to electrical heterogeneity in canine ventricle

  • AC Zygmunt, GT Eddlestone, GP Thomas, RJ Goodrow, C. Antzelevitch
  • Am J Physiol Heart Circ Physiol 281: H689–H697,
  • 2001
1 Excerpt

Arrhythmogenic mechanisms: automaticity, triggered activity, and reentry

  • NS Peters, C Cabo, AL. Wit
  • Cardiac Electrophysiology : From Cell to Bedside
  • 2000
1 Excerpt

Effects of [K ]o on electrical restitution and spatiotemporal organization during ventricular fibrillation

  • ML Koller, ML Riccio, RF Jr.Gilmour
  • Am J Physiol Heart Circ Physiol 279: H2665–H2672,
  • 2000
2 Excerpts

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