Ionic mechanism of electrical alternans.

@article{Fox2002IonicMO,
  title={Ionic mechanism of electrical alternans.},
  author={Jeffrey J. Fox and Jennifer L McHarg and Robert F. Gilmour},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 2},
  pages={H516-30}
}
Although alternans of action potential duration (APD) is a robust feature of the rapidly paced canine ventricle, currently available ionic models of cardiac myocytes do not recreate this phenomenon. To address this problem, we developed a new ionic model using formulations of currents based on previous models and recent experimental data. Compared with existing models, the inward rectifier K(+) current (I(K1)) was decreased at depolarized potentials, the maximum conductance and rectification of… CONTINUE READING
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