Ionic mechanism of diphenylhydantoin action on glucose-induced insulin release.

Abstract

Diphenylhydantoin inhibits glucose-stimulated insulin release. The mode of action of diphenylhydantoin was investigated by characterizing its effect on 86Rb and 45Ca fluxes in isolated pancreatic islets. The inhibition of glucose-stimulated insulin release by diphenylhydantoin was apparently not attributable to activation of a Na+ + K+ATPase as… (More)

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Cite this paper

@article{Herchuelz1981IonicMO, title={Ionic mechanism of diphenylhydantoin action on glucose-induced insulin release.}, author={Andr{\'e} Herchuelz and Philippe Lebrun and Abdullah Sener and Willy Jean Malaisse}, journal={European journal of pharmacology}, year={1981}, volume={73 2-3}, pages={189-97} }