Ionic liquids as potential enhancers for transdermal drug delivery.

@article{Monti2017IonicLA,
  title={Ionic liquids as potential enhancers for transdermal drug delivery.},
  author={Daniela Monti and Emanuele Egiziano and Susi Burgalassi and Patrizia Chetoni and Cinzia Chiappe and Angelo Sanzone and Silvia Tampucci},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={516 1-2},
  pages={
          45-51
        }
}
The aim of this study was to verify the effect of several cyclic onium based ionic liquids (ILs), including mono- and dicationic derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO), a dialkyl morpholinium salt and a Brønsted acidic IL, as enhancers of the in vitro transdermal permeation and skin retention of diltiazem through and into hairless rat skin. The drug was used as both the hydrochloride salt (DZHCl) and the free base (DZB) to highlight the relationship between the enhancement effect… CONTINUE READING

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IAJPS 2018 , 05 ( 05 ) , 3751-3760 Dobhal Nidhi

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