Ionic interactions promote transmembrane helix-helix association depending on sequence context.


Folding and oligomerization of integral membrane proteins frequently depend on specific interactions of transmembrane helices. Interacting amino acids of helix-helix interfaces may form complex motifs and exert different types of molecular forces. Here, a set of strongly self-interacting transmembrane domains (TMDs), as isolated from a combinatorial library… (More)
DOI: 10.1016/j.jmb.2009.11.054