Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation.

@article{Pandit2005IonicDO,
  title={Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation.},
  author={Sandeep V. Pandit and Omer Berenfeld and Justus M. B. Anumonwo and Roman M. Zaritski and James Kneller and Stanley Nattel and Jos{\'e} Jalife},
  journal={Biophysical journal},
  year={2005},
  volume={88 6},
  pages={
          3806-21
        }
}
Recent studies suggest that atrial fibrillation (AF) is maintained by fibrillatory conduction emanating from a small number of high-frequency reentrant sources (rotors). Our goal was to study the ionic correlates of a rotor during simulated chronic AF conditions. We utilized a two-dimensional (2-D), homogeneous, isotropic sheet (5 x 5 cm(2)) of human atrial cells to create a chronic AF substrate, which was able to sustain a stable rotor (dominant frequency approximately 5.7 Hz, rosette-like tip… CONTINUE READING

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