Ionic currents that generate the spontaneous diastolic depolarization in individual cardiac pacemaker cells.

@article{Shibata1985IonicCT,
  title={Ionic currents that generate the spontaneous diastolic depolarization in individual cardiac pacemaker cells.},
  author={Erwin F. Shibata and Wayne R Giles},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 22},
  pages={7796-800}
}
An enzymatic dispersion procedure has been developed to obtain viable, spontaneously active single myocytes from cardiac pacemaker tissue: the bullfrog (Rana catesbeiana) sinus venosus. Recordings of time- and voltage-dependent Ca2+ and K+ currents have been made by using a single suction-microelectrode technique. The results show that two time- and voltage… CONTINUE READING