Ionic currents during sustained pacemaker activity in rabbit sino-atrial myocytes.

@article{Zaza1997IonicCD,
  title={Ionic currents during sustained pacemaker activity in rabbit sino-atrial myocytes.},
  author={Antonio Zaza and Martina Micheletti and A. Brioschi and M. S. R. Rocchetti},
  journal={The Journal of physiology},
  year={1997},
  volume={505 ( Pt 3)},
  pages={677-88}
}
1. The contribution of various ionic currents to diastolic depolarization (DD) in rabbit sinoatrial myocytes was evaluated by the action potential clamp technique. Individual currents were identified, during sustained pacemaking activity reproduced under voltage clamp conditions, according to their sensitivity to specific channel blockers. 2. The current sensitive to dihydropyridines (DHPs), blockers of L-type Ca2+ current (ICa,L), was small and outward during most of DD. Diastolic DHP… CONTINUE READING

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