Ionic control of enzymic degradation of double-stranded RNA.

  title={Ionic control of enzymic degradation of double-stranded RNA.},
  author={Salvatore Sorrentino and Antonella Carsana and Alberto Furia and J. Doskocil and Massimo Libonati},
  journal={Biochimica et biophysica acta},
  volume={609 1},
The pattern of the degradation of various double-stranded polyribonucleotides by several ribonucleases (bovine RNAase A and its cross-linked dimer, bovine seminal RNAase, and pike-whale pancreatic RNAase) has been studied as a function of ionic strength and pH. It appears that (1) there is no direct correlation between the secondary structure of double-stranded RNA and its resistance against enzymatic breakdown, i.e., the stability of the secondary structure of double-helical RNA is not the… CONTINUE READING