Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine.

@article{Moghaddam1989IonicCO,
  title={Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine.},
  author={Bita Moghaddam and Bejamin S Bunney},
  journal={Journal of neurochemistry},
  year={1989},
  volume={53 2},
  pages={652-4}
}
While using the technique of in vivo microdialysis, we have assessed the effect of the ionic composition of the perfusing solution on extracellular dopamine levels during resting conditions and following a pharmacological manipulation. Our results indicate that perfusion with solutions containing the ionic composition of commercially available Ringer's solution, which mimic the ionic composition of plasma as opposed to brain extracellular fluid, alters the turnover rate and basal release of… CONTINUE READING
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