Ionic channels in vascular endothelial cells.

  title={Ionic channels in vascular endothelial cells.},
  author={David J Adams},
  journal={Trends in cardiovascular medicine},
  volume={4 1},
Vascular endothelial cells respond to neurohumoral and physical stimuli to secrete mediators that modulate blood pressure and tissue perfusion. The initial response of endothelial cells usually involves an elevation of cytoplasmic Ca(2+), due to Ca(2+) release from intracellular stores and Ca(2+) influx from the extracellular space, and subsequent activation of Ca(2+)-dependent enzymes. The activation of cell-surface receptors by vasoactive substances stimulates Ca(2+) entry via plasmalemmal… CONTINUE READING

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Hemodynamic shear stress activates a K’ current in vascular endothelial cells

  • S-P Olesen, DE Clapham, PF Davies
  • Nature 331:168-170
  • 1988
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