Ionic basis of tonic firing in spinal substantia gelatinosa neurons of rat.

@article{Melnick2004IonicBO,
  title={Ionic basis of tonic firing in spinal substantia gelatinosa neurons of rat.},
  author={Igor V Melnick and S{\'o}nia F. A. Santos and Karolina Szokol and Peter Szucs and Boris V. Safronov},
  journal={Journal of neurophysiology},
  year={2004},
  volume={91 2},
  pages={646-55}
}
Ionic conductances underlying excitability in tonically firing neurons (TFNs) from substantia gelatinosa (SG) were studied by the patch-clamp method in rat spinal cord slices. Ca(2+)-dependent K(+) (K(CA)) conductance sensitive to apamin was found to prolong the interspike intervals and stabilize firing evoked by a sustained membrane depolarization. Suppression of Ca(2+) and K(CA) currents, however, did not abolish the basic pattern of tonic firing, indicating that it was generated by voltage… CONTINUE READING
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