Ionic basis of the action potential prolongation in ventricular myocytes from Syrian hamsters with dilated cardiomyopathy.

@article{Thuringer1996IonicBO,
  title={Ionic basis of the action potential prolongation in ventricular myocytes from Syrian hamsters with dilated cardiomyopathy.},
  author={Dominique Thuringer and Edith Deroubaix and Alain Coulombe and Edouard Coraboeuf and J. J. Mercadier},
  journal={Cardiovascular research},
  year={1996},
  volume={31 5},
  pages={747-57}
}
OBJECTIVE The aim of our study was to determine the main electrophysiological alterations associated with cardiac dilation in MS200 strain Syrian hamsters, a model of genetically determined cardiomyopathy. METHODS Ventricular action potentials (APs) were recorded with standard microelectrodes in isolated hearts from 120-day-old cardiomyopathic (strain MS200) and age-matched control (strain CHF148) Syrian hamsters. Ionic currents were recorded from single ventricular myocytes using the whole… CONTINUE READING

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