Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages.


OBJECTIVE The aim was to determine the ionic basis of action potential lengthening associated with cardiac hypertrophy. METHODS Action potentials and ionic currents of left ventricular myocytes isolated from normal and hypertrophied hearts were recorded with patch pipettes. Since cardiac hypertrophy is a time dependent process, myocytes isolated from… (More)


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