Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes.

@article{Workman1999IonicBO,
  title={Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes.},
  author={Antony J. Workman and Kathleen A. Kane and Andrew C. Rankin},
  journal={Cardiovascular research},
  year={1999},
  volume={43 4},
  pages={
          974-84
        }
}
OBJECTIVES Firstly, to compare effects of adenosine on membrane potential and refractoriness in AV nodal and atrial cells. Secondly, to assess the contribution of the effects of adenosine on IKAdo and ICaL to its effects on the functional electrophysiological properties in the two cell types. METHODS The whole cell patch clamp technique was used to record action potentials and ion currents in AV nodal and left atrial myocytes isolated enzymatically from rabbit hearts. RESULTS Adenosine (10… CONTINUE READING
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Ionic basis temperatures and relevance to action potential

  • L Belardinelli, JC Shryock, Y Song, D Wang, M. Srinivas
  • Am J Physiol of the electrophysiological actions…
  • 1995
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