Ionic basis for the intrinsic activation of rat supraoptic neurones by hyperosmotic stimuli.


1. Magnocellular neurosecretory cells (MNCs) were impaled in the supraoptic nucleus of rat hypothalamic explants maintained in vitro. Current- and voltage-clamp analysis of the osmotically induced response was performed at 34 degrees C. 2. Addition of mannitol or NaCl to cause a rise in fluid osmolarity (greater than +6 mosM) caused a membrane… (More)


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