Ionic and structural specificity effects of natural and synthetic polyamines on the aggregation and resolubilization of single-, double-, and triple-stranded DNA.

@article{Saminathan1999IonicAS,
  title={Ionic and structural specificity effects of natural and synthetic polyamines on the aggregation and resolubilization of single-, double-, and triple-stranded DNA.},
  author={Manjini Saminathan and Tresa Remya Thomas Antony and Akira Shirahata and Leonard H. Sigal and T J Thomas},
  journal={Biochemistry},
  year={1999},
  volume={38 12},
  pages={3821-30}
}
DNA condensation, precipitation, and aggregation are related phenomena involving DNA-DNA interactions in the presence of multivalent cations, and studied for their potential implications in DNA packaging in the cell. Recent studies have shown that the condensation/aggregation is a prerequisite for the cellular uptake of DNA for gene therapy applications. To elucidate the ionic and structural factors involved in DNA aggregation, we studied the precipitation and resolubilization of high molecular… CONTINUE READING