Ionic and radical oxidations of DNA by hydrogen peroxide.

Abstract

Hydrogen peroxide mediated oxidation of 2'-deoxyadenosine and isolated DNA was investigated. Reaction of hydrogen peroxide with 2'-deoxyadenosine under non radical conditions led to the formation of a predominant decomposition product. This was identified as 2'-deoxyadenosine N-1-oxide on the basis of detailed 1H and 13C NMR analysis and further confirmed… (More)

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