Ionic Liquids as Active Pharmaceutical Ingredients

@article{Ferraz2011IonicLA,
  title={Ionic Liquids as Active Pharmaceutical Ingredients},
  author={R. Ferraz and L. Branco and C. Prud{\^e}ncio and J. Noronha and Ž. Petrovski},
  journal={ChemMedChem},
  year={2011},
  volume={6}
}
Ionic liquids (ILs) are ionic compounds that possess a melting temperature below 100 °C. Their physical and chemical properties are attractive for various applications. Several organic materials that are now classified as ionic liquids were described as far back as the mid‐19th century. The search for new and different ILs has led to the progressive development and application of three generations of ILs: 1) The focus of the first generation was mainly on their unique intrinsic physical and… Expand
Ionic liquids based active pharmaceutical ingredients
Aims: Salt formation of active pharmaceutical ingredients (APIs) improve their aqueous solubility, processing at industrial level, safety aspects and sometimes biological properties. The aim of theExpand
Ionic liquids based active pharmaceutical ingredients
Aims: Salt formation of active pharmaceutical ingredients (APIs) improve their aqueous solubility, processing at industrial level, safety aspects and sometimes biological properties. The aim of theExpand
Pharmaceutical Salts: Solids to Liquids by Using Ionic Liquid Design
Ionic liquids (ILs) have attracted increasing interest lately in several areas such as chemistry, physics, engineering, material science, molecular biochemistry, energy and fuels, among others.Expand
Ionic liquids in biomedical application
Abstract Ionic liquid belongs to the class of organic salt with melting temperature, generally below 100 °C. Those having melting point below room temperature are termed as room temperature ionicExpand
Biocompatible ionic liquids and their applications in pharmaceutics
Ionic liquids (ILs) have been used as solvents or materials, or both, in many applications, including pharmaceutics and medicine due to their exceptional properties consisting of the combination ofExpand
Bondonic Chemistry: Predicting Ionic Liquids' (IL) Bondons by Raman-IR Spectra
The notable nowadays physical-chemical structures as ionic liquids (ILs) are, due to their versatility properties adjusted by changing either the anion or cation sides, with spread applications asExpand
Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine.
TLDR
The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Expand
Selected issues related to the toxicity of ionic liquids and deep eutectic solvents—a review
TLDR
Ionic liquids and deep eutectic solvents have been the most promising discoveries in the world of Green Chemistry in recent years, and DESs seem to be a less toxic alternative to ionic liquids. Expand
'Pro et contra' ionic liquid drugs - Challenges and opportunities for pharmaceutical translation.
  • A. Balk, U. Holzgrabe, L. Meinel
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2015
TLDR
The review connects the interrelated chemical, physical, pharmaceutical, and toxicological outcome of API-ILs, serving as guidance for the formulation scientist who aims at expanding ones armamentarium for poorly water soluble APIs while avoiding structural modification, thereof. Expand
Evaluation of solubility and partition properties of ampicillin-based ionic liquids.
TLDR
A modular ionic liquid synthetic strategy for improved APIs is explored, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts to enhance the solubility and bioavailability of L-ampicillin forms. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 86 REFERENCES
The third evolution of ionic liquids: active pharmaceutical ingredients
A modular, ionic liquid (IL)-based strategy allows compartmentalized molecular level design of a wide range of new materials with tunable biological, as well as the well known physical and chemical,Expand
On the Chemical Stabilities of Ionic Liquids
TLDR
This review focuses on the non-innocent nature of ionic liquids, with a decided emphasis to clearly illuminate the ability of Ionic liquids to affect the mechanistic aspects of some organic reactions thereby affecting and promoting the yield and selectivity. Expand
New frontiers in materials science opened by ionic liquids.
TLDR
Recent studies on ILs that are employed as functional advanced materials, advanced mediums for materials production, and components for preparing highly functional materials are reviewed. Expand
Crystalline vs. Ionic Liquid Salt Forms of Active Pharmaceutical Ingredients: A Position Paper
TLDR
The current industry reliance on crystalline APIs is examined and challenged by discussing the breadth and potential impact of liquid salts as a possible approach to phase control. Expand
Ionic liquid based microemulsion with pharmaceutically accepted components: Formulation and potential applications.
TLDR
A novel ionic liquid-in-oil (IL/o) microemulsion which is able to dissolve pharmaceuticals that are insoluble or sparingly soluble in water and most of pharmaceutical grade organic liquids and may offer novel opportunities to develop a potential drug delivery carrier for poorly soluble drugs molecules is reported. Expand
Hydroformylation in room temperature ionic liquids (RTILs): catalyst and process developments.
TLDR
Over the last few years, ionic liquids have successfully been applied as alternative solvents for homogeneous biphasic catalysis, and an important advantage is the possibility to tune their solubility and acidity/coordination properties by varying the nature of the anions and cations systematically. Expand
Ionic Liquids: Physicochemical Properties
This comprehensive database on physical properties of pure ionic liquids (ILs) contains data collected from 269 peer-reviewed papers in the period from 1982 to June 2008. There are more than 9,400Expand
Room temperature ionic liquids and their mixtures: potential pharmaceutical solvents.
TLDR
The solvency of alkyl imidazolium salts (PF(6)(-)Br(-)Cl(-)) for poorly water-soluble model drugs, albendazole and danazol, is reported, indicating their potential application as pharmaceutical solvents/cosolvents. Expand
Water-immiscible room temperature ionic liquids (RTILs) as drug reservoirs for controlled release.
TLDR
This paper explores some relevant properties of the hexafluorophosphate (PF6(-)) salts of butyl, hexyl and octyl-3-methylimidazolium cations (BMIM, HMIM, OMIM, respectively). Expand
Ionic liquid applications : pharmaceuticals, therapeutics, and biotechnology
Preface 1. Ionic Liquids as Pharmaceutical Salts: A Historical Perspective Vineet Kumar and Sanjay V. Malhotra 2. Ionic Liquids: New Opportunities for the Chemistry of Amino Acids, Peptides, andExpand
...
1
2
3
4
5
...