Ionic Hydrogen Bonds and Lipid Packing Defects Determine the Binding Orientation and Insertion Depth of RecA on Multicomponent Lipid Bilayers.

@article{Zhang2016IonicHB,
  title={Ionic Hydrogen Bonds and Lipid Packing Defects Determine the Binding Orientation and Insertion Depth of RecA on Multicomponent Lipid Bilayers.},
  author={Leili Zhang and Manohary Rajendram and Douglas B. Weibel and Arun Yethiraj and Qiang Cui},
  journal={The journal of physical chemistry. B},
  year={2016},
  volume={120 33},
  pages={8424-37}
}
We describe a computational and experimental approach for probing the binding properties of the RecA protein at the surface of anionic membranes. Fluorescence measurements indicate that RecA behaves differently when bound to phosphatidylglycerol (PG)- and cardiolipin (CL)-containing liposomes. We use a multistage computational protocol that integrates an implicit membrane/solvent model, the highly mobile mimetic membrane model, and the full atomistic membrane model to study how different… CONTINUE READING
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Anionic Phospholipids Interact with RecA and Stabilize Nucleoprotein Filaments in Escherichia coli

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