Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes.

@article{Antzelevitch2007IonicMA,
  title={Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes.},
  author={Charles Antzelevitch},
  journal={Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology},
  year={2007},
  volume={9 Suppl 4},
  pages={iv4-15}
}
Torsade de pointes (TdP) is a life-threatening arrhythmia that develops as a consequence of a reduction in the repolarization reserve of cardiac cells leading to amplification of electrical heterogeneities in the ventricular myocardium as well as to the development of early after depolarization-induced triggered activity. Electrical heterogeneities within the ventricles are due to differences in the time course of repolarization of the three predominant cell types that make up the ventricular… CONTINUE READING