Ion transporters in brain tumors.

@article{Cong2015IonTI,
  title={Ion transporters in brain tumors.},
  author={Damin Cong and Wen ‐ Qing Zhu and Kristopher T. Kahle and Shaoshan Hu and Dandan Sun},
  journal={Current medicinal chemistry},
  year={2015},
  volume={22 10},
  pages={
          1171-81
        }
}
Ion transporters are important in regulation of ionic homeostasis, cell volume, and cellular signal transduction under physiological conditions. They have recently emerged as important players in cancer progression. In this review, we discussed two important ion transporter proteins, sodium-potassium-chloride cotransporter isoform 1 (NKCC-1) and sodium-hydrogen exchanger isoform 1 (NHE-1) in Glioblastoma multiforme (GBM) and other malignant tumors. NKCC-1 is a Na(+)- dependent Cl(-) transporter… CONTINUE READING
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