Ion specific effects of alkali cations on the catalytic activity of HIV-1 protease.

@article{Pokorn2013IonSE,
  title={Ion specific effects of alkali cations on the catalytic activity of HIV-1 protease.},
  author={Jana Pokorn{\'a} and Jan Heyda and Jan Konvalinka},
  journal={Faraday discussions},
  year={2013},
  volume={160},
  pages={359-70; discussion 389-403}
}
Human immunodeficiency virus 1 protease (HIV-1 PR), an important therapeutic target for the treatment of AIDS, is one of the most well-studied enzymes. However, there is still much to learn about the regulation of the activity and inhibition of this key viral enzyme. Specifically, the mechanism of activation of HIV-1 PR from the viral polyprotein upon HIV maturation is still not understood. It has been suggested that external factors like pH or salt concentration might contribute to regulation… CONTINUE READING