Ion selectivity in potassium channels.

  title={Ion selectivity in potassium channels.},
  author={Sergei Yu Noskov and Beno{\^i}t Roux},
  journal={Biophysical chemistry},
  volume={124 3},
Potassium channels are tetrameric membrane-spanning proteins that provide a selective pore for the conduction of K(+) across the cell membranes. One of the main physiological functions of potassium channels is efficient and very selective transport of K(+) ions through the membrane to the cell. Classical views of ion selectivity are summarized within a historical perspective, and contrasted with the molecular dynamics (MD) simulations free energy perturbation (FEP) performed on the basis of the… CONTINUE READING