Ion reactivity of calcium-deficient hydroxyapatite in standard cell culture media.

@article{Gustavsson2011IonRO,
  title={Ion reactivity of calcium-deficient hydroxyapatite in standard cell culture media.},
  author={Juhan Gustavsson and Maria Pau M Ginebra and Elisabeth Engel and Josep Ant{\'o}n Planell},
  journal={Acta biomaterialia},
  year={2011},
  volume={7 12},
  pages={4242-52}
}
Solution-mediated surface reactions occur for most calcium phosphate-based biomaterials and may influence cellular response. A reasonable extrapolation of such processes observed in vitro to in vivo performance requires a deep understanding of the underlying mechanisms. We therefore systematically investigated the nature of ion reactivity of calcium-deficient hydroxyapatite (CDHA) by exposing it for different periods of time to standard cell culture media of different chemical composition (DMEM… CONTINUE READING

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