Ion-pair Reversed-phase High-performance Liquid Chromatography of Ondansetron Hydrochloride Using Sodium Heptanesulphonate as a Counterion

@inproceedings{VARVARA2009IonpairRH,
  title={Ion-pair Reversed-phase High-performance Liquid Chromatography of Ondansetron Hydrochloride Using Sodium Heptanesulphonate as a Counterion},
  author={ANDREEA VARVARA and CRINA-MARIA MONCIU and CORINA ARAM and Claudia Raluca Popescu},
  year={2009}
}
A simple and selective isocratic HPLC method for the determination of ondansetron hydrochloride has been developed. The separation is achieved by ion-pair reversed-phase chromatography on a Ultrasphere C8 column. A mixture of 0.3% sodium heptanesulphonate in phosphate buffer solution pH 3.0 and methanol (40/60, V/V) is used as mobile phase. The influence of pH, mobile phase composition and concentration of organic modifier on capacity factor of ondansetron has been investigated. The HPLC system… CONTINUE READING

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