Ion mobility mass spectrometry of proteins and protein assemblies.

  title={Ion mobility mass spectrometry of proteins and protein assemblies.},
  author={Charlotte Uetrecht and Rebecca J. Rose and Esther van Duijn and Kristina Lorenzen and Albert J. R. Heck},
  journal={Chemical Society reviews},
  volume={39 5},
Traditionally, mass spectrometry has been a powerful analytical method enabling the structural analysis of small molecules, and later on peptides and proteins. With the advent of native mass spectrometry, using a combination of electrospray ionisation and time of flight analysis, mass spectrometry could also be applied to the mass determination of large protein complexes such as ribosomes and whole viruses. More recently, ion mobility has been coupled to mass spectrometry providing a new… CONTINUE READING
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