Ion mobility – mass spectrometry : a new paradigm for proteomics

@inproceedings{McLean2005IonM,
  title={Ion mobility – mass spectrometry : a new paradigm for proteomics},
  author={John A McLean and Brandon T Ruotolo and Kent J Gillig and David H Russell},
  year={2005}
}
Matrix-assisted laser desorption/ionization (MALDI) coupled with ion mobility–mass spectrometry (IM–MS) provides a rapid ( s–ms) means for the two-dimensional (2D) separation of complex biological samples (e.g., peptides, oligonucleotides, glycoconjugates, lipids, etc.), elucidation of solvent-free secondary structural elements (e.g., helices, -hairpins, random coils, etc.), rapid identification of posttranslational modifications (e.g., phosphorylation, glycosylation, etc.) or ligation of small… CONTINUE READING

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