Ion-mediated nucleic acid helix-helix interactions.

  title={Ion-mediated nucleic acid helix-helix interactions.},
  author={Zhi-Jie Tan and Shi-Jie Chen},
  journal={Biophysical journal},
  volume={91 2},
Salt ions are essential for the folding of nucleic acids. We use the tightly bound ion (TBI) model, which can account for the correlations and fluctuations for the ions bound to the nucleic acids, to investigate the electrostatic free-energy landscape for two parallel nucleic acid helices in the solution of added salt. The theory is based on realistic atomic structures of the helices. In monovalent salt, the helices are predicted to repel each other. For divalent salt, while the mean-field… CONTINUE READING
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